Fresh analysis indicates that individuals who stop using popular slimming jabs like Mounjaro or Wegovy may regain lost weight much more quickly than those who halt conventional diet and exercise programs.
Findings released in a leading medical journal demonstrates that while obese individuals often shed about a fifth of their total mass while on the medication, the mass comes back at an average rate of 0.8 kg per month after stopping.
"People using these medications need to be informed of the potential of rapid rebound weight gain when the treatment concludes," cautioned lead investigator Dr. Susan Jebb.
This pace of recovery means a reversion to pre-treatment weight in about 18 months.
Analyzing Approaches
The study, which looked at dozens of trials involving thousands of participants, contrasted the results of GLP-1 agonists with other pills.
Scientists note that individuals who shed pounds through diet and exercise typically see a more gradual creep back—perhaps 0.1 kg a month—after stopping.
The Reason for the Fast Regain
Doctors believe the way of the drugs is key to understanding the heightened rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate appetite.
"Sustained high doses of the hormone concentrations far above than the body's typical production could lead to the system to produce less of its endogenous GLP-1, and could reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Stopping of this GLP-1 'fix' leads to hunger is uncontrolled, making binge eating far more likely."
A Chronic Issue?
Health authorities advise the jabs for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, considering the significant potential of weight regain, the therapy should be considered long-term.
This perspective is supported by pharmaceutical companies, who note that the results "underscore the chronic character of excess weight," akin to managing diseases like high blood pressure.
Patient Accounts
People who have come off the medication report a intense return of cravings.
"It felt as if something flipping and you're instantly ravenous," described a patient.
The struggle is compounded if users have not established sustainable dietary or behavioural modifications during treatment.
Significant Adoption
Recent estimates suggest that a significant number of adults in the UK have used these injections in the past year, with desire continuing to grow.
- Use is greater among women than males.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private healthcare rather than the NHS.
In conclusion, researchers caution that while GLP-1 drugs are potent agents for shedding pounds, they are not a permanent cure and lasting health benefits likely depends on integrated behavioural management.